LingVitae was founded back in 2002, with the main purpose of developing the innovative Design Polymers technology as a complement for second and third generation DNA sequencing platforms. The patented technology amplifies and digitizes the quaternary information encoded in biological DNA, through the synthesis of Design Polymers. The conversion of biological DNA into Design Polymers simplifies the process of identifying the bases when sequencing DNA. The technology is still being evaluated for its future potential in the ever emerging nanopore sequencing field.
In parallel LingVitae developed the novel platform independent sample preparation technology Tiled End Sequencing (TES). The technology allows for an improved bioinformatical sequence assembly of longer DNA targets in order to ease next generation sequencing protocols that have shorter read-lengths. TES is currently being developed in a collaborative effort with Royal Institute of Technology with promising data.
In 2008 LingVitae acquired an extensive patent portfolio for life science applications on optical disk format.
In 2009 Plarion Ltd was founded with key personnel out of the ashes of the Center of Excellency at Plasmon, an industry leader for 30 years within optical disk development. The companies have since developed a proprietary readout technology specifically for the platform in order to realise a medium-throughput low cost sequencing platform. The project is still in the research phase and currently aiming for proof-of-concept by end of 2011.
December 2009 Lingvitae, together with Plarion, Royal Institute of Technology, Karolinska Institute, and the French Corrosion Institute received a Seventh Framework Programme EU grant (FP7) to develop a DNA sequencing technology that meets the price-performance parameters required to make DNA analysis at the nucleotide level part of everyday work life. The first year cycle of the project is currently being concluded with innovated scientific breakthroughs (see the Digital Sequencing website).
At current LingVitae/Plarion are co-developing the DVD-platform for a versatile use in biological diagnostic applications. The DVD instrument offers an advanced laser scanning microscope backed up by the DVD instrument development production lines. With minor custom built designs to off the-shelf components we can offer a low-cost instrumentation and disposables to address biological diagnostic needs including but not limited to:
- Real-time isothermal DNA/RNA signature tracking
- ELISA-like antibody-antigen interaction screening
- Sub-micron imaging capabilities
- DNA sequencing
- Blood and chemical analysis